Modifying L-Type Calcium Current Kinetics: Consequences for Cardiac Excitation and Arrhythmia Dynamics

The L-type Ca current (I(Ca,L)), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking I(Ca,L) can prevent ventricular fibrillation, but only at levels suppressing contractility. We speculated that, instead of b...

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Главные авторы: Mahajan, Aman, Sato, Daisuke, Shiferaw, Yohannes, Baher, Ali, Xie, Lai-Hua, Peralta, Robert, Olcese, Riccardo, Garfinkel, Alan, Qu, Zhilin, Weiss, James N.
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2008
Предметы:
Biophysical Theory and Modeling
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157257/
https://ncbi.nlm.nih.gov/pubmed/18160661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.98590
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