Modifying L-Type Calcium Current Kinetics: Consequences for Cardiac Excitation and Arrhythmia Dynamics

The L-type Ca current (I(Ca,L)), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking I(Ca,L) can prevent ventricular fibrillation, but only at levels suppressing contractility. We speculated that, instead of b...

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Bibliografiske detaljer
Main Authors: Mahajan, Aman, Sato, Daisuke, Shiferaw, Yohannes, Baher, Ali, Xie, Lai-Hua, Peralta, Robert, Olcese, Riccardo, Garfinkel, Alan, Qu, Zhilin, Weiss, James N.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2008
Fag:
Biophysical Theory and Modeling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157257/
https://ncbi.nlm.nih.gov/pubmed/18160661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.98590
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