Modifying L-Type Calcium Current Kinetics: Consequences for Cardiac Excitation and Arrhythmia Dynamics

The L-type Ca current (I(Ca,L)), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking I(Ca,L) can prevent ventricular fibrillation, but only at levels suppressing contractility. We speculated that, instead of b...

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Detalhes bibliográficos
Main Authors: Mahajan, Aman, Sato, Daisuke, Shiferaw, Yohannes, Baher, Ali, Xie, Lai-Hua, Peralta, Robert, Olcese, Riccardo, Garfinkel, Alan, Qu, Zhilin, Weiss, James N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Biophysical Theory and Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157257/
https://ncbi.nlm.nih.gov/pubmed/18160661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.98590
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