MECHANISM OF ACTION OF A-769662, A VALUABLE TOOL FOR ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE

We have studied the mechanism of A-769662, a new activator of AMP-activated protein kinase (AMPK). Unlike other pharmacological activators it directly activates native rat AMPK by mimicking both effects of AMP, i.e. allosteric activation and inhibition of dephosphorylation. It has no effect on the i...

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Détails bibliographiques
Auteurs principaux: Göransson, Olga, McBride, Andrew, Hawley, Simon A., Ross, Fiona A., Shpiro, Natalia, Foretz, Marc, Viollet, Benoit, Hardie, D. Grahame, Sakamoto, Kei
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156105/
https://ncbi.nlm.nih.gov/pubmed/17855357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706536200
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