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Acetylcholine Receptor Gating: Movement in the α-Subunit Extracellular Domain

Acetylcholine receptor channel gating is a brownian conformational cascade in which nanometer-sized domains (“Φ blocks”) move in staggering sequence to link an affinity change at the transmitter binding sites with a conductance change in the pore. In the α-subunit, the first Φ-block to move during c...

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Detalhes bibliográficos
Main Authors: Purohit, Prasad, Auerbach, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151656/
https://ncbi.nlm.nih.gov/pubmed/18040059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709858
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