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Ca(2+)–Secretion Coupling Is Impaired in Diabetic Goto Kakizaki rats

The Goto Kakizaki (GK) rat is a widely used animal model to study defective glucose-stimulated insulin release in type-2 diabetes (T2D). As in T2D patients, the expression of several proteins involved in Ca(2+)-dependent exocytosis of insulin-containing large dense-core vesicles is dysregulated in t...

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Bibliografske podrobnosti
Main Authors: Rose, Tobias, Efendic, Suad, Rupnik, Marjan
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151625/
https://ncbi.nlm.nih.gov/pubmed/17535961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609604
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