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Chemical Disulfide Mapping Identifies an Inhibitor Cystine Knot in the Agouti Signaling Protein

The agouti signaling protein (ASIP) and its homolog, the agouti-related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals. NMR investigations find that the C-terminal domains of these proteins adopt a fold consistent with an Inhibitor...

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書誌詳細
主要な著者: Yu, Bin, Millhauser, Glenn L.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151477/
https://ncbi.nlm.nih.gov/pubmed/17997984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.10.062
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