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Chemical Disulfide Mapping Identifies an Inhibitor Cystine Knot in the Agouti Signaling Protein
The agouti signaling protein (ASIP) and its homolog, the agouti-related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals. NMR investigations find that the C-terminal domains of these proteins adopt a fold consistent with an Inhibitor...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151477/ https://ncbi.nlm.nih.gov/pubmed/17997984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.10.062 |
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