Loop Swapped Chimeras of the Agouti-related Protein (AgRP) and the Agouti Signaling Protein (ASIP) Identify Contacts Required for Melanocortin 1 Receptor (MC1R) Selectivity and Antagonism

Agouti related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocortin receptors (MCRs). Signaling specificity is mediated in part through receptor...

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Detalhes bibliográficos
Main Authors: Patel, Mira P., Fabersunne, Camila S. Cribb, Yang, Ying-kui, Kaelin, Christopher B., Barsh, Gregory S., Millhauser, Glenn L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972358/
https://ncbi.nlm.nih.gov/pubmed/20831872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.08.054
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