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Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a

The homomeric acid-sensing ion channel 1a (ASIC1a) is a H(+)-activated ion channel with important physiological functions and pathophysiological impact in the central nervous system. Here we show that homomeric ASIC1a is distinguished from other ASICs by a reduced response to successive acid stimula...

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Detalhes bibliográficos
Main Authors: Chen, Xuanmao, Gründer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151377/
https://ncbi.nlm.nih.gov/pubmed/17204502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.120733
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