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Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells exhibit rapid glucose consumption, with most of the glucose-derived carbon being secreted as lactate despite abundant oxygen availability (the Warburg effect). Here, we u...

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מידע ביבליוגרפי
Main Authors: DeBerardinis, Ralph J., Mancuso, Anthony, Daikhin, Evgueni, Nissim, Ilana, Yudkoff, Marc, Wehrli, Suzanne, Thompson, Craig B.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148292/
https://ncbi.nlm.nih.gov/pubmed/18032601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709747104
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