Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells exhibit rapid glucose consumption, with most of the glucose-derived carbon being secreted as lactate despite abundant oxygen availability (the Warburg effect). Here, we u...

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Bibliographic Details
Main Authors: DeBerardinis, Ralph J., Mancuso, Anthony, Daikhin, Evgueni, Nissim, Ilana, Yudkoff, Marc, Wehrli, Suzanne, Thompson, Craig B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148292/
https://ncbi.nlm.nih.gov/pubmed/18032601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709747104
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