Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

The formation of amyloid fibrils is a common biochemical characteristic that occurs in Alzheimer's disease and several other amyloidoses. The unifying structural feature of amyloid fibrils is their specific type of β-sheet conformation that differentiates these fibrils from the products of norm...

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Detaylı Bibliyografya
Asıl Yazarlar: Habicht, Gernot, Haupt, Christian, Friedrich, Ralf P., Hortschansky, Peter, Sachse, Carsten, Meinhardt, Jessica, Wieligmann, Karin, Gellermann, Gerald P., Brodhun, Michael, Götz, Jürgen, Halbhuber, Karl-Jürgen, Röcken, Christoph, Horn, Uwe, Fändrich, Marcus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148273/
https://ncbi.nlm.nih.gov/pubmed/18042730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703793104
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