Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria

BACKGROUND: Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall. Pathogenic mycobacteria carry mycolic acid sub-types that contain cyclopropane rings. Double bonds at specific sites on mycolic acid pre...

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Autori principali: Alahari, Anuradha, Trivelli, Xavier, Guérardel, Yann, Dover, Lynn G., Besra, Gurdyal S., Sacchettini, James C., Reynolds, Robert C., Coxon, Geoffrey D., Kremer, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147073/
https://ncbi.nlm.nih.gov/pubmed/18094751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001343
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