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The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins

The GNAS1 gene encodes the α subunit of the G protein G(s), which couples receptor binding by several hormones to activation of adenylate cyclase. Null mutations of GNAS1 cause pseudohypoparathyroidism (PHP) type Ia, in which hormone resistance occurs in association with a characteristic osteodystro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hayward, Bruce E., Kamiya, Mamoru, Strain, Lisa, Moran, Veronica, Campbell, Roderick, Hayashizaki, Yoshihide, Bonthron, David T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21457/
https://ncbi.nlm.nih.gov/pubmed/9707596
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