Imprinting of the G(s)α gene GNAS1 in the pathogenesis of acromegaly

Approximately 40% of growth hormone–secreting pituitary adenomas have somatic mutations in the GNAS1 gene (the so-called gsp oncogene). These mutations at codon 201 or codon 227 constitutively activate the α subunit of the adenylate cyclase–stimulating G protein G(s). GNAS1 is subject to a complex p...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hayward, Bruce E., Barlier, Anne, Korbonits, Márta, Grossman, Ashley B., Jacquet, Philippe, Enjalbert, Alain, Bonthron, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
Assuntos:
Rapid Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC208949/
https://ncbi.nlm.nih.gov/pubmed/11254676
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados