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A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsensecontaining mRNAs in mammalian cells

All eukaryotic cells analyzed have developed mechanisms to eliminate the production of mRNAs that prematurely terminate translation. The mechanisms are thought to exist to protect cells from the deleterious effects of in-frame nonsense codons that are generated by routine inefficiencies and inaccura...

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Bibliografski detalji
Glavni autori: Sun, Xiaolei, Perlick, Haley A., Dietz, Harry C., Maquat, Lynne E.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21452/
https://ncbi.nlm.nih.gov/pubmed/9707591
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