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N-terminally tagged prion protein supports prion propagation in transgenic mice.

The eight amino acid sequence, Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys, representing the FLAG peptide, was inserted after codons 22 or 88 of the mouse (Mo) prion protein (PrP) gene. Inclusion of the FLAG sequence at these locations interfered neither with the cellular processing of PrPC nor its conversion i...

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Main Authors: Telling, G. C., Tremblay, P., Torchia, M., Dearmond, S. J., Cohen, F. E., Prusiner, S. B.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144756/
https://ncbi.nlm.nih.gov/pubmed/9098892
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