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p31(comet) Blocks Mad2 Activation through Structural Mimicry
The status of spindle checkpoint signaling depends on the balance of two opposing dynamic processes that regulate the highly unusual two-state behavior of Mad2. In mitosis, a Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerization and converts Mad2 to a conformer ame...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2144745/ https://ncbi.nlm.nih.gov/pubmed/18022368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.08.048 |
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