Determinants of conformational dimerization of Mad2 and its inhibition by p31(comet)

The spindle assembly checkpoint (SAC) monitors chromosome attachment to spindle microtubules. SAC proteins operate at kinetochores, scaffolds mediating chromosome-microtubule attachment. The ubiquitous SAC constituents Mad1 and Mad2 are recruited to kinetochores in prometaphase. Mad2 sequesters Cdc2...

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Bibliographische Detailangaben
Hauptverfasser: Mapelli, Marina, Filipp, Fabian V, Rancati, Giulia, Massimiliano, Lucia, Nezi, Luigi, Stier, Gunter, Hagan, Robert S, Confalonieri, Stefano, Piatti, Simonetta, Sattler, Michael, Musacchio, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1422169/
https://ncbi.nlm.nih.gov/pubmed/16525508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601033
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