Accumulation of Mad2–Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae

The spindle assembly checkpoint (SAC) coordinates mitotic progression with sister chromatid alignment. In mitosis, the checkpoint machinery accumulates at kinetochores, which are scaffolds devoted to microtubule capture. The checkpoint protein Mad2 (mitotic arrest deficient 2) adopts two conformatio...

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Bibliografiske detaljer
Main Authors: Nezi, Luigi, Rancati, Giulia, De Antoni, Anna, Pasqualato, Sebastiano, Piatti, Simonetta, Musacchio, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064158/
https://ncbi.nlm.nih.gov/pubmed/16818718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200602109
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