Conformational changes in the NS3 protease from hepatitis C virus strain Bk monitored by limited proteolysis and mass spectrometry.

Conformational changes occurring within the NS3 protease domain from the hepatitis C virus Bk strain (NS3(1-180)) under different physico-chemical conditions either in the absence or in the presence of its cofactor Pep4A were investigated by limited proteolysis experiments. Because the surface acces...

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Bibliographic Details
Main Authors: Orrù, S., Dal Piaz, F., Casbarra, A., Biasiol, G., De Francesco, R., Steinkühler, C., Pucci, P.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144388/
https://ncbi.nlm.nih.gov/pubmed/10422832
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