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The effect of prime-site occupancy on the hepatitis C virus NS3 protease structure

We recently reported a new class of inhibitors of the chymotrypsin-like serine protease NS3 of the hepatitis C virus. These inhibitors exploit the binding potential of the S` site of the protease, which is not generally used by the natural substrates. The effect of prime-site occupancy was analyzed...

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Detalhes bibliográficos
Main Authors: Casbarra, Annarita, Piaz, Fabrizio Dal, Ingallinella, Paolo, Orrù, Stefania, Pucci, Piero, Pessi, Antonello, Bianchi, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373603/
https://ncbi.nlm.nih.gov/pubmed/12192066
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