Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate.

We have determined the three-dimensional solution structure of the complex of Lactobacillus casei dihydrofolate reductase and the anticancer drug trimetrexate. Two thousand seventy distance, 345 dihedral angle, and 144 hydrogen bond restraints were obtained from analysis of multidimensional NMR spec...

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Détails bibliographiques
Auteurs principaux: Polshakov, V. I., Birdsall, B., Frenkiel, T. A., Gargaro, A. R., Feeney, J.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 1999
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144292/
https://ncbi.nlm.nih.gov/pubmed/10091649
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