3H-n.m.r. studies of multiple conformations and dynamic processes in complexes of folate and methotrexate with Lactobacillus casei dihydrofolate reductase.

[7,3',5'-3H3]- and [7,9-3H3]-folic acid and [7,3',5'-3H3]methotrexate (MTX) have been prepared and 3H-n.m.r. spectra obtained for their complexes with Lactobacillus casei dihydrofolate reductase (DHFR). The 3H results confirm the presence of three pH-dependent different conformat...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Curtis, N, Moore, S, Birdsall, B, Bloxsidge, J, Gibson, C L, Jones, J R, Feeney, J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1994
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137341/
https://ncbi.nlm.nih.gov/pubmed/7980397
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