19F-n.m.r. studies of 3',5'-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes.

19F-n.m.r. spectroscopy was used to study the binding of 3',5'-difluoromethotrexate to dihydrofolate reductase (tetrahydrofolate dehydrogenase) from Lactobacillus casei. The benzoyl ring of the bound difluoromethotrexate was found to 'flip' about its symmetry axis, and the rate (...

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Detalles Bibliográficos
Main Authors: Clore, G M, Gronenborn, A M, Birdsall, B, Feeney, J, Roberts, G C
Formato: Artigo
Idioma:Inglês
Publicado: 1984
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1153266/
https://ncbi.nlm.nih.gov/pubmed/6424648
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