19F-n.m.r. studies of 3',5'-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes.

19F-n.m.r. spectroscopy was used to study the binding of 3',5'-difluoromethotrexate to dihydrofolate reductase (tetrahydrofolate dehydrogenase) from Lactobacillus casei. The benzoyl ring of the bound difluoromethotrexate was found to 'flip' about its symmetry axis, and the rate (...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Clore, G M, Gronenborn, A M, Birdsall, B, Feeney, J, Roberts, G C
Formato: Artigo
Idioma:Inglês
Publicado em: 1984
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1153266/
https://ncbi.nlm.nih.gov/pubmed/6424648
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados