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Modulation of antibody affinity by a non-contact residue.

Antibody LB4, produced by a spontaneous variant of the murine anti-digoxin monoclonal antibody 26-10, has an affinity for digoxin two orders of magnitude lower than that of the parent antibody due to replacement of serine with phenylalanine at position 52 of the heavy chain variable region (Schildba...

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Bibliografske podrobnosti
Main Authors: Schillbach, J. F., Near, R. I., Bruccoleri, R. E., Haber, E., Jeffrey, P. D., Novotny, J., Sheriff, S., Margolies, M. N.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1993
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2142342/
https://ncbi.nlm.nih.gov/pubmed/8443598
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