Contribution of a single heavy chain residue to specificity of an anti-digoxin monoclonal antibody.

Two distinct spontaneous variants of the murine anti-digoxin hybridoma 26-10 were isolated by fluorescence-activated cell sorting for reduced affinity of surface antibody for antigen. Nucleotide and partial amino acid sequencing of the variant antibody variable regions revealed that 1 variant had a...

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Main Authors: Schildbach, J. F., Shaw, S. Y., Bruccoleri, R. E., Haber, E., Herzenberg, L. A., Jager, G. C., Jeffrey, P. D., Panka, D. J., Parks, D. R., Near, R. I.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2142714/
https://ncbi.nlm.nih.gov/pubmed/8061604
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