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Small molecule regulators of autophagy identified by an image-based high-throughput screen
Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the accumulation of misfolded proteins in neurons and may be involved in chronic neurodegenerative dise...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2141901/ https://ncbi.nlm.nih.gov/pubmed/18024584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709695104 |
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