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Pharmacological Inhibition of Neuronal NADPH Oxidase Protects against 1-Methyl-4-Phenylpyridinium (MPP(+))-Induced Oxidative Stress and Apoptosis in Mesencephalic Dopaminergic Neuronal Cells
Oxidative stress is widely recognized as a key mediator of degenerative processes in Parkinson’s disease (PD). Recently, we demonstrated that the dopaminergic toxin MPP(+) initiates oxidative stress to cause caspase-3-dependent apoptotic cell death in mesencephalic dopaminergic neuronal (N27) cells....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2140261/ https://ncbi.nlm.nih.gov/pubmed/17904225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2007.08.008 |
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