Pharmacological Inhibition of Neuronal NADPH Oxidase Protects against 1-Methyl-4-Phenylpyridinium (MPP(+))-Induced Oxidative Stress and Apoptosis in Mesencephalic Dopaminergic Neuronal Cells

Oxidative stress is widely recognized as a key mediator of degenerative processes in Parkinson’s disease (PD). Recently, we demonstrated that the dopaminergic toxin MPP(+) initiates oxidative stress to cause caspase-3-dependent apoptotic cell death in mesencephalic dopaminergic neuronal (N27) cells....

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Bibliographic Details
Main Authors: Anantharam, Vellareddy, Kaul, Siddharth, Song, Chunjuan, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140261/
https://ncbi.nlm.nih.gov/pubmed/17904225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2007.08.008
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