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Discovery of Novel Isoxazolines as Anti-tuberculosis Agents
Nitrofuranyl isoxazolines with increased proteolytic stability over nitrofuranyl amides were designed and synthesized leading to discovery of several compounds with potent in vitro anti-tuberculosis activity. However, their in vivo activity was limited by high protein binding and poor distribution....
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2140235/ https://ncbi.nlm.nih.gov/pubmed/17937983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.048 |
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