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Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A
The signaling lipid molecule 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) has multiple cellular functions, including anti-inflammatory and antineoplastic activities. Here, we report that 15d-PGJ2 blocks translation through inactivation of translational initiation factor eIF4A. Binding of 15d-PGJ...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2140107/ https://ncbi.nlm.nih.gov/pubmed/18034160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601920 |
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