The Anti-inflammatory Prostaglandin 15-Deoxy-Δ(12,14)-PGJ(2) Inhibits CRM1-dependent Nuclear Protein Export

The signaling molecule 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been described as the “anti-inflammatory prostaglandin.” Here we show that substrates of the nuclear export receptor CRM1 accumulate in the nucleus in the presence of 15d-PGJ(2), identifying this prostaglandin as a regulato...

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Detalhes bibliográficos
Main Authors: Hilliard, Mark, Frohnert, Cornelia, Spillner, Christiane, Marcone, Simone, Nath, Annegret, Lampe, Tina, Fitzgerald, Desmond J., Kehlenbach, Ralph H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903415/
https://ncbi.nlm.nih.gov/pubmed/20457605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131821
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