PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells

Chemoattractants such as formyl-Met-Leu-Phe (fMLP) induce neutrophils to polarize by triggering divergent pathways that promote formation of a protrusive front and contracting back and sides. RhoA, a Rho GTPase, stimulates assembly of actomyosin contractile complexes at the sides and back. We show h...

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Bibliographic Details
Main Authors: Wong, Kit, Van Keymeulen, Alexandra, Bourne, Henry R.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140022/
https://ncbi.nlm.nih.gov/pubmed/18086913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706167
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