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Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism
Chemoattractants like fMet-Leu-Phe (fMLP) induce neutrophils to polarize with phosphatidylinositol 3,4,5-trisphosphate (PIP3) and protrusive F-actin at the front and actomyosin contraction at the sides and back. RhoA and its downstream effector, myosin II, mediate the “backness” response, which loca...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450135/ https://ncbi.nlm.nih.gov/pubmed/16537448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600092103 |
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