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Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism

Chemoattractants like fMet-Leu-Phe (fMLP) induce neutrophils to polarize with phosphatidylinositol 3,4,5-trisphosphate (PIP3) and protrusive F-actin at the front and actomyosin contraction at the sides and back. RhoA and its downstream effector, myosin II, mediate the “backness” response, which loca...

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書誌詳細
主要な著者: Wong, Kit, Pertz, Olivier, Hahn, Klaus, Bourne, Henry
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450135/
https://ncbi.nlm.nih.gov/pubmed/16537448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600092103
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