Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

A new class of 16-membered macrolides, the epothilones (Epos), has been synthesized and evaluated for antitumor potential in vitro and in vivo. Recent studies in these and other laboratories showed that epothilones and paclitaxel (paclitaxel) share similar mechanisms of action in stabilizing microtu...

Descripció completa

Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Chou, Ting-Chao, Zhang, Xiu-Guo, Balog, Aaron, Su, Dai-Shi, Meng, Dongfang, Savin, Kenneth, Bertino, Joseph R., Danishefsky, Samuel J.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1998
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21392/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9642
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!