Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

A new class of 16-membered macrolides, the epothilones (Epos), has been synthesized and evaluated for antitumor potential in vitro and in vivo. Recent studies in these and other laboratories showed that epothilones and paclitaxel (paclitaxel) share similar mechanisms of action in stabilizing microtu...

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Bibliographische Detailangaben
Hauptverfasser: Chou, Ting-Chao, Zhang, Xiu-Guo, Balog, Aaron, Su, Dai-Shi, Meng, Dongfang, Savin, Kenneth, Bertino, Joseph R., Danishefsky, Samuel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21392/
https://ncbi.nlm.nih.gov/pubmed/9689134
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