Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

A new class of 16-membered macrolides, the epothilones (Epos), has been synthesized and evaluated for antitumor potential in vitro and in vivo. Recent studies in these and other laboratories showed that epothilones and paclitaxel (paclitaxel) share similar mechanisms of action in stabilizing microtu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chou, Ting-Chao, Zhang, Xiu-Guo, Balog, Aaron, Su, Dai-Shi, Meng, Dongfang, Savin, Kenneth, Bertino, Joseph R., Danishefsky, Samuel J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21392/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9642
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