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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
Prion diseases are characterized by accumulation of misfolded prion protein (PrP(Sc)), and neuronal death by apoptosis. Here we show that nanomolar concentrations of purified PrP(Sc) from mouse scrapie brain induce apoptosis of N2A neuroblastoma cells. PrP(Sc) toxicity was associated with an increas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC213791/ https://ncbi.nlm.nih.gov/pubmed/14532116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg537 |
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