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Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c

Adenine deoxynucleosides, such as 2-chloro-2′-deoxyadenosine (2CdA) induce apoptosis in quiescent lymphocytes, and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. However, it has remained puzzling why deoxyadenosine and its analogs are toxic to a cell that is not un...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Leoni, Lorenzo M., Chao, Qi, Cottam, Howard B., Genini, Davide, Rosenbach, Michael, Carrera, Carlos J., Budihardjo, Imawati, Wang, Xiaodong, Carson, Dennis A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21379/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689121/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9567
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