Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c

Adenine deoxynucleosides, such as 2-chloro-2′-deoxyadenosine (2CdA) induce apoptosis in quiescent lymphocytes, and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. However, it has remained puzzling why deoxyadenosine and its analogs are toxic to a cell that is not un...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Leoni, Lorenzo M., Chao, Qi, Cottam, Howard B., Genini, Davide, Rosenbach, Michael, Carrera, Carlos J., Budihardjo, Imawati, Wang, Xiaodong, Carson, Dennis A.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1998
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9567
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