Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c

Adenine deoxynucleosides, such as 2-chloro-2′-deoxyadenosine (2CdA) induce apoptosis in quiescent lymphocytes, and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. However, it has remained puzzling why deoxyadenosine and its analogs are toxic to a cell that is not un...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Leoni, Lorenzo M., Chao, Qi, Cottam, Howard B., Genini, Davide, Rosenbach, Michael, Carrera, Carlos J., Budihardjo, Imawati, Wang, Xiaodong, Carson, Dennis A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9567
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