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ZAP-70 Protein Tyrosine Kinase Is Constitutively Targeted to the T Cell Cortex Independently of its SH2 Domains

ZAP-70 is a nonreceptor protein tyrosine kinase that is essential for signaling via the T cell antigen receptor (TCR). ZAP-70 becomes phosphorylated and activated by LCK protein tyrosine kinase after interaction of its two NH(2)-terminal SH2 domains with tyrosine-phosphorylated subunits of the activ...

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Detalhes bibliográficos
Main Authors: Huby, Russell D.J., Iwashima, Makio, Weiss, Arthur, Ley, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2137816/
https://ncbi.nlm.nih.gov/pubmed/9199177
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