T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles

Recombinant viral or virus-like particles offer new tools for vaccine development. This study investigated hepatitis B core antigen (HBcAg) capsids and RNA phage Qβ coats as carriers of a foreign epitope to induce antibody responses in mice. HBcAg capsids were shown to induce T cell-independent (TI)...

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Bibliographic Details
Main Authors: Fehr, Thomas, Skrastina, Dace, Pumpens, Paul, Zinkernagel, Rolf M.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21363/
https://ncbi.nlm.nih.gov/pubmed/9689105
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