Intrapatient Dose Escalation of Anti–CTLA-4 Antibody in Patients With Metastatic Melanoma

We previously reported our experience in treating 56 patients with metastatic melanoma using a human anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibody. Durable tumor regressions were seen that correlated with the induction of autoimmune toxicities. In this study, we treated 46 additional patie...

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Hauptverfasser: Maker, Ajay V., Yang, James C., Sherry, Richard M., Topalian, Suzanne L., Kammula, Udai S., Royal, Richard E., Hughes, Marybeth, Yellin, Michael J., Haworth, Leah R., Levy, Catherine, Allen, Tamika, Mavroukakis, Sharon A., Attia, Peter, Rosenberg, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134804/
https://ncbi.nlm.nih.gov/pubmed/16799341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.cji.0000208259.73167.58
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