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The J-related Segment of Tim44 Is Essential for Cell Viability: A Mutant Tim44 Remains in the Mitochondrial Import Site, but Inefficiently Recruits mtHsp70 and Impairs Protein Translocation

Tim44 is a protein of the mitochondrial inner membrane and serves as an adaptor protein for mtHsp70 that drives the import of preproteins in an ATP-dependent manner. In this study we have modified the interaction of Tim44 with mtHsp70 and characterized the consequences for protein translocation. By...

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Main Authors: Merlin, Alessio, Voos, Wolfgang, Maarse, Ammy C., Meijer, Michiel, Pfanner, Nikolaus, Rassow, Joachim
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133122/
https://ncbi.nlm.nih.gov/pubmed/10352014
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