Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum

Here we provide definitive evidence that chloroquine (CQ) uptake in Plasmodium falciparum is determined by binding to ferriprotoporphyrin IX (FPIX). Specific proteinase inhibitors that block the degradation of hemoglobin and stop the generation of FPIX also inhibit CQ uptake. Food vacuole enzymes ca...

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Main Authors: Bray, Patrick G., Janneh, Omar, Raynes, Kaylene J., Mungthin, Mathirut, Ginsburg, Hagai, Ward, Stephen A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1999
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133118/
https://ncbi.nlm.nih.gov/pubmed/10209030
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