Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum

Here we provide definitive evidence that chloroquine (CQ) uptake in Plasmodium falciparum is determined by binding to ferriprotoporphyrin IX (FPIX). Specific proteinase inhibitors that block the degradation of hemoglobin and stop the generation of FPIX also inhibit CQ uptake. Food vacuole enzymes ca...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Bray, Patrick G., Janneh, Omar, Raynes, Kaylene J., Mungthin, Mathirut, Ginsburg, Hagai, Ward, Stephen A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 1999
Ämnen:
Regular Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133118/
https://ncbi.nlm.nih.gov/pubmed/10209030
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk