Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum

Here we provide definitive evidence that chloroquine (CQ) uptake in Plasmodium falciparum is determined by binding to ferriprotoporphyrin IX (FPIX). Specific proteinase inhibitors that block the degradation of hemoglobin and stop the generation of FPIX also inhibit CQ uptake. Food vacuole enzymes ca...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Bray, Patrick G., Janneh, Omar, Raynes, Kaylene J., Mungthin, Mathirut, Ginsburg, Hagai, Ward, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 1999
Assuntos:
Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133118/
https://ncbi.nlm.nih.gov/pubmed/10209030
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares