Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum

Here we provide definitive evidence that chloroquine (CQ) uptake in Plasmodium falciparum is determined by binding to ferriprotoporphyrin IX (FPIX). Specific proteinase inhibitors that block the degradation of hemoglobin and stop the generation of FPIX also inhibit CQ uptake. Food vacuole enzymes ca...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Bray, Patrick G., Janneh, Omar, Raynes, Kaylene J., Mungthin, Mathirut, Ginsburg, Hagai, Ward, Stephen A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 1999
विषय:
Regular Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133118/
https://ncbi.nlm.nih.gov/pubmed/10209030
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